Siem Reap is the major airport with many good connections especially with Thailand.
Cambodia is no longer just the haunt of the hardiest of explorers and there are land connections with Thailand, Vietnam and Laos. It is possible to use buses to cross over from Thailand or Vietnam.
There is a river border crossing between Cambodia and Vietnam on the banks of the Mekong. There are regular fast passenger boats between Vietnam and Cambodia and there are also a couple of luxurious river boats ¬running all the way to the temples of Angkor.